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What antihistamine is best for sleep? Sleep aids: The options Diphenhydramine (Benadryl, Aleve PM, others). Diphenhydramine is a sedating antihistamine. Doxylamine succinate (Unisom SleepTabs). Doxylamine is also a sedating antihistamine. Melatonin. The hormone melatonin helps control your natural sleep-wake cycle. Valerian.
How long does it take for Unisom to get out of your system? Unisom contains an antihistamine called diphenhydramine, which temporarily blocks the histamine action that can cause alertness in the Central Nervous System (CNS). You can take Unisom about 30 minutes before bedtime. The sedative action of Unisom may last up to 6 hours.
Does Zzzquil really work? Diphenhydramine, the main ingredient of ZzzQuil, is only modestly effective in improving sleep according to research. Studies suggest that people fall asleep on average about 8 minutes faster compared to placebo. The total amount of sleep improves by an average of about 12 minutes.
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